What is it about?
This study was conducted to describe the postnatal development of ocular structures in Sprague-Dawley (SD) rats during the first month of age using histology and immunohistochemistry (IHC).
Featured Image
Why is it important?
An important challenge in preclinical juvenile toxicity studies is the absence of age-matched controls when as unscheduled deaths include found dead and preterminal euthanasia unscheduled deaths occur prior to the end of the study. In addition to having to adequately identify xenobiotic-related lesions, pathologists evaluating juvenile tissues must also recognize developmental abnormalities and must not misinterpret physiological developmental changes as xenobioticassociated lesions. Therefore, an understanding of the normal postnatal developmental histological features of various organs is required to avoid erroneous conclusions.
Perspectives
This manuscript can be used as a reference for normal changes occurring in neonatal and juvenile rat eyes. It is useful for researchers with a focus on eyes, toxicopathologists working on juvenile studies, or diagnosticians.
Dr Marie-Odile Benoit-Biancamano
Universite de Montreal
Read the Original
This page is a summary of: Neonatal and Juvenile Ocular Development in Sprague-Dawley Rats: A Histomorphological and Immunohistochemical Study, Veterinary Pathology, November 2017, SAGE Publications,
DOI: 10.1177/0300985817738098.
You can read the full text:
Contributors
The following have contributed to this page
