What is it about?
In humans and domestic animals, sites of mast cell proliferation, designated mastocytosis (not mast cell tumor), include a vareity of internal visceral organs and tissues, but it is unusual that mast cells prominently proliferate within the blood vessel walls. I have detected the presence of mastocytosis located selectively to the internal layer (tunica intima) of the blood vessels (portal vein branches) in the liver of cattle.
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Why is it important?
Lesions of mastocytosis were simultaneously associated with marked fibrous (collagen fibers) deposition. This may mean the mechanism of mast cell-fibroblast interaction. Although the lesions represented a newly recognized variant of matocytosis in the bovine species, it remains undetermined why mast cells proliferated exclusively in the tunica intima of the hepatic portal branches. When researching the in vivo behavior of mast cells, the findings would probably be a useful reference.
Perspectives
In the field of human and veterinary medicine, it may be preferable to consider mastocytosis when evaluating hepatic diseases. In addition, rigorous study of mastocytosis is desirable in the future, with the hope of determining etiology and treatment strategies.
Susumu Ohfuji
Read the Original
This page is a summary of: Hepatic Mastocytosis in Japanese Black Cattle, Veterinary Pathology, October 2017, SAGE Publications,
DOI: 10.1177/0300985817736115.
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