What is it about?
To investigate whether neurofilament light polypeptide (NfL) level in cerebrospinal fluid (CSF), currently a prognostic biomarker of neurodegeneration in patients with multiple sclerosis (MS), may be a potential biomarker of cognitive dysfunction in MS.
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Why is it important?
This study provides preliminary evidence for an association between CSF NfL levels and cognition in progressive forms of MS, which requires validation in larger samples.An inversely proportional association between CSF NfL levels and BICAMS z-scores was found in progressive forms of MS (rp = -0.944).
Perspectives
Many factors contribute to cognitive decline in MS, The detailed analysis of the CSF may through some light in the neurochemical and cellular interactions which occur in the perpetual mechanisms which result to cognitive impairment
Professor Stavros J Baloyannis or Balogiannis or Balojannis or Baloyiannis or Mpalogiannis
Aristotle University of Thessaloniki
Read the Original
This page is a summary of: Does cognitive dysfunction correlate with neurofilament light polypeptide levels in the CSF of patients with multiple sclerosis?, Journal of International Medical Research, April 2019, SAGE Publications,
DOI: 10.1177/0300060519840550.
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