Descriptive analysis of microglia movement and neuronal loss over time after stroke.

What is it about?

This publication investigates microglia process dynamics, or more specifically the lack there of, in areas of secondary neurodegneration after stroke. Microglia appear to have lost a conserved response to localized damage in areas in SND. This publication establishes the time line of impaired process extension towards damage sites and connects it to the development of neuronal loss occurring over time.

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Why is it important?

Microglia facilitate a multitude of functions within the healthy and pathological brain, many of which require cellular and process movement. The observation that a highly conserved feature of microglia- process extension towards laser damage- is impaired in areas of post-stroke SND is striking and might provide a better understanding of the processes occurring and contributing to neuronal loss.