What is it about?
A simple way of combining chemicals in the basis of common pathological endpoints for the purposes of risk assessment.
Featured Image
Photo by Joao Marcelo Marques on Unsplash
Why is it important?
We are exposed to multiple chemicals on a daily basis but experimentally few mixtures have been tested for their cumulative toxicity. This pragmatic approach avoids the need for additional toxicity studies and fully utilises the available data in a sound, scientific manner.
Perspectives
This is the first example of what has been attempted bu the European regulatory assessors in a simplified way that clearly introduces too many wrong endpoints for it to be workable. Our modifications provide a sound pathological basis fir combining chemicals in the liver which can be extended to other organ systems
John Foster
Read the Original
This page is a summary of: The Cumulative Risk Assessment of Hepatotoxic Chemicals: A Hepatic Histopathology Perspective, Toxicologic Pathology, January 2020, SAGE Publications,
DOI: 10.1177/0192623319895481.
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