What is it about?
Our objective was to develop a simple and accurate technique to evaluate the rat fetus and placenta.
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Why is it important?
Our whole-fetus serial sectioning technique resulted in 12 precise cutting planes that fit on 3 histological slides, enabling the examination of most organs without labor-intensive dissection. Quantitative analysis of placental areas improves the understanding of the pathogenesis of treatment-related changes. Since being familiar with the characteristics of normal fetal and placenta development is essential to recognize the effects of treatment, it is necessary to fully characterize these tissues in a normal state.
Perspectives
This technique provides a standardized method for future research in pertinent fields such as developmental biology and toxicology.
Dr Marie-Odile Benoit-Biancamano
Universite de Montreal
Read the Original
This page is a summary of: Histomorphologic Analysis of the Late-term Rat Fetus and Placenta, Toxicologic Pathology, February 2018, SAGE Publications,
DOI: 10.1177/0192623318755135.
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