H pylori in dyspepsia

What is it about?

The present study is done to study different aspects of Helicobacter pylori such as its prevalence, association with upper gastrointestinal pathology, diagnosis and treatment outcome. Gastric antral biopsy and serology for Helicobacter pylori was done for all dyspeptic patients. Histopathology, gram stain and biopsy urease test was done from the gastric biopsy specimen. The prevalence of Helicobacter pylori infection was 58.8%. The sensitivity, specificity, positive and negative predictive value for histopathology was 96.9%, 100%, 100% & 95.8%; for biopsy urease test 80.4%, 100%. 100% & 78.2%; for gram stain 85.6%, 97.1%, 97.6% & 82.5% and for serology 94.8%, 77.9%, 86% & 91.4% respectively. Mostly peptic ulcer and duodenitis cases followed by chronic active gastritis were associated with H Pylori infection. Repeat biopsy revealed eradication of Helicobacter pylori in 90.7% cases. In dyspeptic patients endoscopic biopsy not only detects Helicobacter pylori infection, but also reveals different gastric pathologies.

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Why is it important?

Though the role of H pylori in dyspepsia is well known, its prevalence in different areas should be determined to alert the public and medical practioner both. Role of gram stain is highlighted in this study in touch smear samples which was not done previously by many authors.

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