What is it about?
Functional odontoblasts were differentiated from induced pluripotent stem cells (iPSC) in vitro and in vivo. In vitro, the iPSC were treated with odontogenic medium and expressed markers of odontoblastic differentiation (DMP-!, DSPP and MEPE). After, cells were implanted in mice and generated a dental pulp with tubular dentin.
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Why is it important?
iPSC are cells that can be expanded indefinitely retaining the characteristics after long term expansion. Hence, this cell can be used to test biomaterials without the deleterious effects that cells experience after several passages. Moreover, this work shows for first time that iPSC has been differentiated into odontoblasts that can produce dentin in vivo.
Perspectives
The odontoblasts derived from iPSC open several opportunities to use these cells to test biomaterials, promote pulp regeneration or to study tooth development.
Vinicius Rosa
National University of Singapore
Read the Original
This page is a summary of: Functional Odontoblastic-Like Cells Derived from Human iPSCs, Journal of Dental Research, September 2017, SAGE Publications,
DOI: 10.1177/0022034517730026.
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