What is it about?

This review explains how the organs-on-a-chip technology could in the near future help to develop safer and more potent drugs to treat diseases. It might also help to understand better the different human organs crosstalk and therefore improve the physiology of currently available in-vitro systems. Finally, the use of cells from a single donor to prepare organoids opens the doors to the patient-on-a-chip technology.

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Why is it important?

Currently, most of the drugs which are being developed and tested on in-vitro systems never reach the market. Most of the drugs tested during the clinical phase are either too toxic or have no specific effects and are therefore withdrawn from the development pipeline. The main reason is that the currently available in-vitro models are not physiological enough and therefore do not allow to determine a drug therapeutic window accurately.

Perspectives

This publication aims at helping people with a scientific background understanding what organ(s)-on-a-chip are, with some examples that could help the reader to prepare and develop his own device.

David Bovard
Philip Morris International

Read the Original

This page is a summary of: Organs-on-a-chip, Toxicology Research and Application, January 2017, SAGE Publications,
DOI: 10.1177/2397847317726351.
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