What is it about?
The debate between LDL-cholesterol level and pleiotropic effect of statin to produce better outcome has been repeated issue. Recent publication about the non-statin effect on cardiovascular outcome (especially on stroke) produced new need to discuss the issue again. In this study, we analyzed the RCTs regarding lipid-lowering therapy for stroke prevention and found that achieved LDL-cholesterol level is important determinant for stroke prevention regardless the type of lipid-lowering therapy.
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Why is it important?
LDL-cholesterol level is the most intuitive and easily accessible target for lipid-lowering therapy. Considering that the current guidelines are debating about the target for lipid-lowering therapy, the result of this study can provide important hint for this issue.
Read the Original
This page is a summary of: Achieved low-density lipoprotein cholesterol level and stroke risk: A meta-analysis of 23 randomised trials, European Journal of Preventive Cardiology, February 2019, SAGE Publications, DOI: 10.1177/2047487319830503.
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