What is it about?
The human methylenetetrahydrofolate reductase (MTHFR) gene plays a crucial role in folate metabolism. Data regarding the influence of MTHFR gene polymorphisms on male fertility status are scarce and conflicting. We determined associations between 3 MTHFR gene polymorphisms (C677T, A1298C, and G1793A), serum folate, and total homocysteine (tHcy) levels, with male fertility status and semen parameters.
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Why is it important?
The MTHFR 677CT and 1298AC polymorphisms are associated with up to a 70% reduction in folate metabolism and hyperhomocysteinemia. Folate status is correlated with a variety of diseases, including neural tube defects, neurological and cognitive disorders, cancer, and cardiovascular disease. Folate plays a crucial role in the regulation of homocysteine homeostasis, in providing methyl groups to maintain transmethylation reactions, and in supplying 1 carbon units to DNA/RNA synthesis.
Read the Original
This page is a summary of: Relationship Between Genetic Polymorphisms of Methylenetetra hydrofolate Reductase (C677T, A1298C, and G1793A) as Risk Factors for Idiopathic Male Infertility, Reproductive Sciences, October 2010, SAGE Publications, DOI: 10.1177/1933719110385135.
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