What is it about?

ABSTRACT Aging is associated with a progressive decline of muscle mass and/or the qualitative impairment of the muscle tissue. There is growing evidence of the prominent role of low-grade chronic inflammation in age-related changes in the neuromuscular system. Age-related muscle loss is characterised a combination of multiple factors, and there is growing evidence for a prominent role of low-grade chronic inflammation in sarcopenia. The purpose of the study was to identify the age-related changes in skeletal muscle properties inflammatory mediators responsible for deficits in functional fitness and to explain whether inflammation is related to changes in body composition and the decline of muscle strength in elderly older men.

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Why is it important?

• The age-related increase of fat storage is a serious source of inflammatory mediators which enhance muscle mass loss. • The high concentrations of inflammatory mediators underlie the low-grade inflammatory status during ageing. • The dominance of inflammatory mediators over the growth factors is responsible for the age-related decline in muscle function. • The reduction of fat content can reverse the muscle strength impairments in elderly men.

Perspectives

In our the current study, the strong dominance of inflammatory mediators H2O2, IL-1β, TNFα and hsCRP over the anabolic factors IGF-1 and PDGFBB in the older adult men were observed, whereas in young men the reverse situation was detected. The enhancement of pro-inflammatory stateincrease in catabolic signals with age was the main cause ofresponsible for deficits in maximum strength muscle and functional capacity. negative modulation of body composition and maximum muscle strength conductive to progress of sarcopenia.However, it is too early to draw a clear conclusion on a clinically relevant relationship between inflammation and skeletal muscle properties due to the small sample size. Therefore, the study will be continue.

Agnieszka Zembroń-Łacny
University of Zielona Gora

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This page is a summary of: The Relation of Inflammaging With Skeletal Muscle Properties in Elderly Men, American Journal of Men s Health, March 2019, SAGE Publications, DOI: 10.1177/1557988319841934.
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