What is it about?
ABSTRACT Aging is associated with a progressive decline of muscle mass and/or the qualitative impairment of the muscle tissue. There is growing evidence of the prominent role of low-grade chronic inflammation in age-related changes in the neuromuscular system. Age-related muscle loss is characterised a combination of multiple factors, and there is growing evidence for a prominent role of low-grade chronic inflammation in sarcopenia. The purpose of the study was to identify the age-related changes in skeletal muscle properties inflammatory mediators responsible for deficits in functional fitness and to explain whether inflammation is related to changes in body composition and the decline of muscle strength in elderly older men.
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Why is it important?
• The age-related increase of fat storage is a serious source of inflammatory mediators which enhance muscle mass loss. • The high concentrations of inflammatory mediators underlie the low-grade inflammatory status during ageing. • The dominance of inflammatory mediators over the growth factors is responsible for the age-related decline in muscle function. • The reduction of fat content can reverse the muscle strength impairments in elderly men.
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This page is a summary of: The Relation of Inflammaging With Skeletal Muscle Properties in Elderly Men, American Journal of Men s Health, March 2019, SAGE Publications,
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