What is it about?
The LAMP3 gene is located on chromosome 3q27, and gene amplification has confirmed that this region is closely related to various tumors. Our previous immunohistochemical staining results showed that expression of LAMP3 in laryngeal squamous cell carcinoma (LSCC) differs significantly from that in corresponding adjacent tissues. In patient-derived tumor xenografts (PDXs) from human tissues, the basic characteristics of tumor tissues, including the microenvironment and histopathology, can be well preserved, thereby providing a suitable in vivo model for tumor research. The expression levels of LAMP3 can be effectively manipulated in mice in a PDX model to determine the efficacy of radiation exposure on tumors. By combining the PDX model with transcriptome analysis, the signaling pathways regulated by LAMP3 can be clearly identified. Thus, by using this molecule as a marker, specific groups of patients may be screened for targeted therapy in the future.
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Why is it important?
It is important to establish effective early diagnostic indicators and reliable treatment strategies for laryngeal squamous cell carcinoma (LSCC). We previously found that expression of LAMP3 was significantly higher in cancerous tissues compared to adjacent normal surgical margin tissues. The present study explored the role of LAMP3 and the related molecular mechanisms in the efficacy of radiation exposure in LSCC. Reduced LAMP3 expression enhanced the efficacy of radiation exposure in LSCC. Thus, by utilizing this molecule as a marker, specific groups of patients may be screened for targeted therapy in the future.
Perspectives
Laryngeal cancer is the most common malignant tumor of the larynx and has the second highest incidence among malignancies of the respiratory tract. Approximately 96% of laryngeal cancers are squamous cell carcinomas. To further understand LSCC development, it is particularly important to establish an appropriate animal model to simulate the clinical characteristics of tumors. The findings of experiments using the constructed LSCC PDX model and cells in the present study suggest that reduced LAMP3 expression enhances the efficacy of radiation exposure in LSCC, which may be a result of regulation of the LAMC2/TNC signaling pathway. The findings provide guidance for individualized treatment of patients with LSCC.
Guohua Wang
Nantong University
Read the Original
This page is a summary of: Highlight article: Efficacy of radiation exposure in laryngeal squamous cell carcinoma is mediated by the LAMP3/LAMC2/tenascin-C pathway, Experimental Biology and Medicine, August 2019, SAGE Publications,
DOI: 10.1177/1535370219867643.
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