Adaptive Returns of Deficient Systemic Plasma Immunoglobulin G Levels as Rehabilitation Biomarker After Emergency Colectomy for Fulminant Ulcerative Colitis

Alexander T Hawkins, Jun W Um, Amosy E M’Koma
  • Clinical Medicine Insights Gastroenterology, January 2017, SAGE Publications
  • DOI: 10.1177/1179552217746692

Understanding inflammatory bowel disease diagnostics and surgical management of ulcerative colitis.

What is it about?

The overall goal of this project is to develop a viable and amenable tool that will permit diagnostic accuracy of inflammatory bowel disease. We have developed a set of criteria (based on serum and tissue profiling) for analyzing specific proteins referred to as a “proteome”. Based on successful convincing novel data, we intend to identify these unique proteins of interest. These proteins appear to differentiate ulcerative colitis from Crohn’s disease of the colon (Crohn's colitis(CC)) and from normal controls. With this tool, physicians will be able to avoid indeterminate colitis (IC) misdiagnoses and prescribe appropriate surgical care for the hitherto IC classified patients. Moreover, our data will also explore the possibility of potential therapeutic target for treating IBD.

Why is it important?

Successful surgical treatment of inflammatory bowel diseases depend on correct diagnosis. Our plan is to develop a viable tool that can allow accurate discrimination of inflammatory bowel disease. An accurate diagnosis prior to initiating medical therapy or performing colectomy surgery is of paramount importance in terms of medical care, surgical intervention, and prognosis. Most IC and CC patients are presumed UC and are operated subsequently are found to develop a recurrent de novo Crohn's disease in the ileal pouch. This is a serious complication that leads to functional failure and may hinder the restoration of intestinal continuity often necessitate a permanent end ileostomy, a complication of which both patients and Doctors would like to avoid.

Perspectives

Dr Amosy E M'Koma (Author)
Meharry Medical College

Data from the published study show restored and normalization of immunoglobulin G in plasma (p-IgG) can be interpreted as a sign of patient rehabilitation rather than a mere immunopathological biomarker. These results are based on correct diagnosis of fulminant UC and indication of emergency colectomy. Adaptive compositional balance of p-IgG is a specific and more reliable diagnostic and/or prognostic tool biomarker demonstrating patient recovery.

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http://dx.doi.org/10.1177/1179552217746692

The following have contributed to this page: Dr Amosy E M'Koma