Hepatocyte Growth Factor/C-Met Axis in Thyroid Cancer: From Diagnostic Biomarker to Therapeutic Target

Maria Trovato, Alfredo Campennì, Salvatore Giovinazzo, Massimiliano Siracusa, Rosaria Maddalena Ruggeri
  • Biomarker Insights, January 2017, SAGE Publications
  • DOI: 10.1177/1177271917701126

Thyroid cancer and HGF/cmet system

What is it about?

HGF/c-met axis plays a crucial role in thyroid cancer development. THis was for different cellular distributions of both ligands and receptors along in the thyroid sequence benign lesions vs malignant proliferations. Further HGF/c-met signals modulate mesenchymal tissue surrounding epithelial cancer cells.

Why is it important?

We define HGF/c-met signals for determining their rules in personalized therapies of cancers.

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http://dx.doi.org/10.1177/1177271917701126

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