What is it about?
Vessel invasion can be discovered by h-caldesmon immunohistochemistry much more efficiently than elastin stains in gastric, pancreatic and colorectal adenocarcinomas.
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Why is it important?
Presence of blood vessel invasion is especially of oncological clinical importance in patients with no lymph node metastasis. Our results show that h-caldesmon is far more superior than desmin and elastin stains. In time, oncologists may be in a position to request the application of this marker to evaluate the presence of vessel invasion.
Perspectives
In various publications dealing with the discovery of vessel invasion, the main emphasis was on endothelial stains. We aimed to target the smooth muscle cells of the vessel structure, and we found that h-caldesmon is the best option for this purpose. Our findings will face numerous feedbacks and cause applications. I performed this study for about seven years. This is hard work and a lot of sweat.
Özgür Ekinci
Gazi Universitesi
Read the Original
This page is a summary of: Compared With Elastin Stains, h-Caldesmon and Desmin Offer Superior Detection of Vessel Invasion in Gastric, Pancreatic, and Colorectal Adenocarcinomas, International Journal of Surgical Pathology, January 2018, SAGE Publications,
DOI: 10.1177/1066896917752442.
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