Cytomegalovirus-associated acute respiratory failure in lupus patients

What is it about?

This is about stories of Cytomegalovirus-associated acute respiratory failure that took place in three lupus patients. For the first time, we have described three patterns of cytomegalovirus-associated acute respiratory failure(ARF), the first originated from cytomegalovirus reactivation, the second resulted from immunoinflammatory response and the third from the combined effect of of acute cytomegalovirus infection and the subsequent immunoinflammatory response. All the patients here presented were responsive to sequential or combined therapeutic protocols.

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Photo by Ross Sokolovski on Unsplash

Photo by Ross Sokolovski on Unsplash

Why is it important?

Infection-associated acute respiratory failure (ARF) in users of immunosuppressive agents occurs frequently and contributes greatly to the mortality. Regard with ARF event, it was previously thought to be arised from bacteria infection or active disease of lupus itself while Cytomegalovirus infection is rarely thought to be involved. We find that there are three patterns of cytomegalovirus-associated acute respiratory failure in lupus patients and propose a novel therapeutic strategy in relation to cytomegalovirus biology.

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