What is it about?
The circadian clock is important for day to day physiological processes. This review discusses basic mechanisms of the circadian clock, the relationship that exists between the molecular clock and hypoxia inducible factors that are upregulated in the presence of low oxygen levels, and the potential role of circadian dysregulation in the cardiopulmonary sequelae associated with obstructive sleep apnea.
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Why is it important?
Although circadian dysregulation has been implicated in development and progression of other diseases, the role of circadian dysregulation and disruption of the molecular clock in cardiopulmonary disease in OSA has not been demonstrated before. This unexplored area of research could help for development of new diagnostic and therapeutic strategies for OSA.
Perspectives
I hope that this article brings to light a relevant topic to the fields of otolaryngology and sleep medicine. Understanding the circadian clock could broaden our understanding of many disease processes and may be especially important for OSA.
Dr. David F Smith
Cincinnati Children's Hospital Medical Center
Read the Original
This page is a summary of: Circadian Dysregulation: The Next Frontier in Obstructive Sleep Apnea Research, Otolaryngology, September 2018, SAGE Publications,
DOI: 10.1177/0194599818797311.
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