Gold Nanoparticles Inhibit Matrix Metalloproteases without Cytotoxicity

M. Hashimoto, J.I. Sasaki, S. Yamaguchi, K. Kawai, H. Kawakami, Y. Iwasaki, S. Imazato
  • Journal of Dental Research, June 2015, SAGE Publications
  • DOI: 10.1177/0022034515589282

Gold Nanoparticles Inhibit Matrix Metalloproteases without Cytotoxicity

What is it about?

The aim of this study was to evaluate MMP inhibition and cytotoxic responses to gold (AuNPs) and platinum nanoparticles (PtNPs) stabilized by polyvinylpyrrolidone (PVP) in cultured murine macrophages (RAW264) by using MMP inhibition assays, measuring cell viability and inflammatory responses (quantitative reverse transcription polymerase chain reaction [RT-qPCR]), and conducting a micromorphological analysis by fluorescence and transmission electron microscopy.

Why is it important?

The negative charge of the surface coating of PVP binds to Zn(2+) from the active center of MMPs by chelate binding and results in MMP inhibition. In summary, AuNPs are attractive NPs that effectively inhibit MMP activity without cytotoxicity or inflammatory responses.

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http://dx.doi.org/10.1177/0022034515589282

The following have contributed to this page: Dr Satoshi Yamaguchi