Raised Fibrinogen Levels and Outcome in Outpatients With Peripheral Artery Disease

Pere Altes, Paulina Perez, Carlos Esteban, Juan Francisco Sánchez Muñoz-Torrero, Eduardo Aguilar, Ana María García-Díaz, Lorenzo Ramón Álvarez, Pedro Enrique Jiménez, Joan Carles Sahuquillo, Manuel Monreal
  • Angiology, November 2017, SAGE Publications
  • DOI: 10.1177/0003319717739720

Outcome of peripheral artery patients with raised fibrinogen levels in plasma

What is it about?

Fibrinogen is a key protein of the coagulation process. We followed 1363 patients of the FRENA registry ("Factores de Riesgo y Enfermedad Arterial") during a mean of 18 months. We have shown that peripheral artery patients with raised levels of this protein in their plasma have worse outcomes in terms of cardiovascular events and bleedings.

Why is it important?

Raised fibrinogen levels, by virtue of its role in thrombus formation, blood viscosity, and platelet aggregation, may enhance atherosclerotic plaque evolution and thus influence outcomes. Our study revealed that outpatients with symptomatic peripheral artery disease and raised fibrinogen levels are at an increased risk of developing new ischemic events (as acute myocardial infarction, stroke or limb amputation because of critical ischemia) or major bleeding. This worse outcome persisted after adjusting for potential confounders. So, its clinical relevance should not be underestimated and should have implications for prevention strategies.


Pere Altes
Universitat Autonoma de Barcelona

Writing this article was a great pleasure as it has co-authors with whom I have had long standing collaborations. This article also make me think over on such an aggressive form of the cardiovascular disease as the peripheral artery disease. This patients have an especial bad outcome and research in this field should be done to improve it.

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