What is it about?

Early intervention in psychosis (EIP) services aim to prevent transition to psychosis and improve outcomes for at-risk young people. Substance use is a modifiable risk factor that substantially influences functioning yet remains understudied in this population. We wanted to understand the patterns of substance use in young people at risk of psychosis using EIP services across Australia. Among 1,966 participants,there were high baseline rates of substance use, reporting past-3-month use of alcohol (60%), cannabis (43%), and tobacco (41%) at treatment entry. Early intervention services were associated with significant reductions in illicit substance use across 6 months, including reduced odds of using cannabis, amphetamine-type stimulants, and nonprescribed sedatives. Reductions in substance use were greater among participants ages ≥18 at treatment entry, whereas tobacco and alcohol use showed minimal improvement during treatment across the age groups.

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Why is it important?

EIP services were associated with reductions in illicit substance use but had limited impact on tobacco use suggesting that targeted strategies to address persistent use of these substances should be integrated into routine EIP care. These findings also support the idea of preventive intervention in the context of increased risk of substance use disorders as future comorbid problems for individuals experience mental ill-health.

Perspectives

Early intervention is such a key element of supporting individuals with or at risk of psychosis. This new research shows just how key it is to embed substance use assessment and treatment into mental health interventions and models of care, and the real difference this can make for young people.

Ellie Brown
University of Melbourne

Read the Original

This page is a summary of: Impact of Early Intervention Services on Substance Use Outcomes Among Young People at Risk for Psychosis, Psychiatric Services, April 2026, American Psychiatric Association,
DOI: 10.1176/appi.ps.20250309.
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