Problems With Noninferiority Designs in PTSD Treatment Research: Losing Signal to Noise

What is it about?

PTSD treatment research needs to reevaluate the use of non-inferiority (NI) trials to establish efficacy and for comparative effectiveness. Their rise in use without effective attention to design differences is reducing the quality of the evidence base to guide effective PTSD treatment. Given limitations, NI studies may be appropriate to compare validated treatment delivered in different modalities or with different subgroups. They are not a substitution for placebo controlled or comparative effectiveness trials.

Featured Image