Interindividual Differences in Cortical Thickness and Their Genomic Underpinnings in Autism Spectrum Disorder

What is it about?

Autism Spectrum Disorder (ASD) is accompanied by highly individualized developmental differences in brain anatomy. However, what causes this inter-individual variation, and how neuroanatomical variability translates to clinical heterogeneity in ASD remains largely unknown. Here, we demonstrate that brain regions that are neuroanatomically different in ASD express more than expected genes that have previously been implicated in the condition; and that distinct clinical ASD subgroups can be linked to specific aspects of neuropathology based on their particular neuroanatomical fingerprint.

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