Low-Dose Testosterone Augmentation for Antidepressant-Resistant Major Depressive Disorder in Women: An 8-Week Randomized Placebo-Controlled Study

What is it about?

Low-dose testosterone has been shown to improve mood, fatigue and sexual function in small studies of women not formally diagnosed with depression. The authors administered low-dose testosterone or placebo cream to women with depression that was resistant to traditional antidepressant therapy. Both the testosterone and placebo groups experienced improvements in mood, fatigue, sexual function, with no differences between the groups. They concluded that testosterone cannot be recommended for antidepressant-resistant major depressive disorder based on the results of this study, and that additional studies may still be warranted given the large placebo effect observed.

Featured Image