Altered Cellular White Matter But Not Extracellular Free Water on Diffusion MRI in Individuals at Clinical High Risk for Psychosis

What is it about?

The authors searched for changes in the brains of subjects at clinical high risk to develop psychosis by applying a new MRI method that quantifies brain tissue and extracellular free water. They found changes that are already present prior to the onset of psychosis in the white matter tissue of at risk subjects, and that are associated with a decline in function. Extracellular water changes were not found, and are expected to play a more prominent role closer to or at onset of psychosis.

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