Cerebellar-Prefrontal Network Connectivity and Negative Symptoms in Schizophrenia

What is it about?

Human neuroimaging studies struggle to prove that discovered networks are causal to disease processes, and not epiphenomena. Here, we have used neuroimaging to find a surprising new network between frontal cortex and the cerebellum that is responsible for negative symptoms in schizophrenia. We then show with non-invasive brain stimulation that recovery of that network’s function improves negative symptoms. This new model of network discovery combined with network validation shows promise in reversing symptoms of schizophrenia that are the most disabling and medication resistant.

Featured Image