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The beneficial impact of the recently FDA-approved xanomeline and trospium chloride on cognitive impairment in schizophrenia is best understood in the context of similar data with a range of first- and second- generation antipsychotic agents. The absence of any head-head studies renders difficult any confident comparison of their therapeutic profiles in schizophrenia.

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This page is a summary of: Does Xanomeline/Trospium Have Unique Benefits for Cognitive Impairment Associated With Schizophrenia?, American Journal of Psychiatry, September 2025, American Psychiatric Association,
DOI: 10.1176/appi.ajp.20250021.
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