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Few options are available for patients who have failed five treatments for their depression. This small open-label study demonstrated significant safety and efficacy of synthetic psilocybin in severe treatment resistant depression and supports further study of psychedelics for this often neglected population.

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This page is a summary of: Single-Dose Psilocybin for Depression With Severe Treatment Resistance: An Open-Label Trial, American Journal of Psychiatry, January 2025, American Psychiatric Association,
DOI: 10.1176/appi.ajp.20231063.
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