Coordinate-Based Network Mapping of Brain Structure in Major Depressive Disorder in Younger and Older Adults: A Systematic Review and Meta-Analysis

What is it about?

Major depressive disorder is characterized by heterogeneous neuroimaging findings, possibly due to the differences in clinical features. This study conducted a meta-analysis of major depressive disorder in younger and older adults with early and late onset of major depression. We found that structural differences affect frontoparietal, dorsal attention, and visual networks both in younger and older adults with major depression; these networks were more affected in older patients with late onset compared to older patients with early onset.

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