What is it about?

This new research uses a brain imaging technique called diffusion tensor imaging (DTI) to provide an insight into how small variations in the brain's wiring system is associated with differences in IQ in both the general population and in disorders such as schizophrenia. Over 40 scientists from around the world were involved in analysing brain MRI scans and measures of cognitive function of 1,717 participants, with both healthy functions and patients with schizophrenia. This resulted in a new method to harmonise data collection and analysis as part of the Enhancing Neuroimaging Genetics through Meta-Analysis project (ENIGMA), Schizophrenia Working Group.

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Why is it important?

These results advance our knowledge in a number of ways. Firstly, it demonstrates that the relationship between brain structure and intelligence not only involves grey matter, but also white matter - the brain’s wiring system. Secondly, it’s not just one part of this wiring system that is important for intelligence, but rather the wiring system as a whole. And finally, the relationship between intelligence and the brain’s wiring system is basically the same in patients with schizophrenia and healthy people, in that the lack of pattern explains their cognitive abilities. This suggests that cognitive function in patients is the same as the general population, at least as far as white matter is concerned.

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This page is a summary of: The Relationship Between White Matter Microstructure and General Cognitive Ability in Patients With Schizophrenia and Healthy Participants in the ENIGMA Consortium, American Journal of Psychiatry, June 2020, American Psychiatric Association,
DOI: 10.1176/appi.ajp.2019.19030225.
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