What is it about?
how FXR activated by bile acids in human and in humanized model represses apoA1 expression the structural protein of HDL thus lowering HDL and increasing potentially deleterious cardio vascular health in humans
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Why is it important?
first cross talk between bile acid physiology and lipid metabolism in human, revealed that FXR antagonists could be useful in humans
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This page is a summary of: Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element, Journal of Clinical Investigation, April 2002, American Society for Clinical Investigation,
DOI: 10.1172/jci200214505.
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