Regeneration of Corneal Epithelium With Dental Pulp Stem Cells Using a Contact Lens Delivery System

Evgeny Kushnerev, Susan G. Shawcross, Shankari Sothirachagan, Fiona Carley, Arun Brahma, Julian M. Yates, M. Chantal Hillarby
  • Investigative Opthalmology & Visual Science, October 2016, Association for Research in Vision and Ophthalmology (ARVO)
  • DOI: 10.1167/iovs.15-17953

Regeneration of the cornea using contact lenses

What is it about?

The corneal epithelium is sloughed off surface of the eye by the action of blinking and is continually replaced by division and maturation of the limbal stem cells (LSCs). In the case of injury or disease, LSCs can be lost or damaged to a point at which the corneal epithelial layer is no longer maintained. leading to LSC deficiencies (LSCDs). When this occurs, the opaque conjunctiva overgrows the anterior surface of the eye, leading to vision impairment or loss.

Why is it important?

Dental pulp stem cells (DPSCs) are promising candidates as autologous LSC substitutes. In this study, contact lenses (CLs) are used as a novel medical device to deliver DPSCs onto corneal surface to enhance corneal epithelium regeneration.

Perspectives

Mr Evgeny Kushnerev

In this study we show that DPSCs, delivered using CLs, can be used to enhance repair and regeneration of the human corneal epithelium.

Read Publication

http://dx.doi.org/10.1167/iovs.15-17953

The following have contributed to this page: Mr Evgeny Kushnerev