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Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease of unknown cause. We found that fibroblasts in the lungs of patients with IPF express greater levels of KCNMB1 which promotes increased activity of the large conductance potassium (BK) channel. This is important in promoting myofibroblast differentiation.
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This page is a summary of: The Role of KCNMB1 and BK Channels in Myofibroblast Differentiation and Pulmonary Fibrosis, American Journal of Respiratory Cell and Molecular Biology, September 2019, American Thoracic Society,
DOI: 10.1165/rcmb.2019-0163oc.
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