GM-CSF removal results in Fatty liver as well as Pulmonary Alveolar Proteinosis

What is it about?

The major pathology in alveolar proteinosis results in airways filling with excess lung surfactant due to removal/inactivation of a regulatory molecule (GM-CSF). Here, we show that complete removal of GM-CSF also leads to fatty liver as well as lung tissue fat build up suggesting that GM-CSF has a wider role in regulating whole body fat metabolism.

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Why is it important?

It provides evidence that GM-CSF has a previously unrecognised role in whole body lipid metabolism (see accompanying editorial)