What is it about?
This research identified inhibition of regulatory-associated protein of mechanistic target of rapamycin as a potentially therapeutic target for the treatment of hyperoxia-induced acute lung injury (HALI) and bronchopulmonary dysplasia (BPD). This study demonstrated increased expression of phospho-beclin1, light chain-3-II, and lysosomal-associated membrane protein 1 in human lung tissues of premature infants with diseases characterized by HALI (i.e., respiratory distress syndrome and BPD).
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Why is it important?
Collectively, our study unveils a novel demonstration of enhancing autophagy and antiapoptotic effects, specifically through the inhibition of RPTOR as a potentially useful therapeutic target for the treatment of hyperoxia-induced acute lung injury and BPD in developing lungs.
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This page is a summary of: Inhibition of Regulatory-Associated Protein of Mechanistic Target of Rapamycin Prevents Hyperoxia-Induced Lung Injury by Enhancing Autophagy and Reducing Apoptosis in Neonatal Mice, American Journal of Respiratory Cell and Molecular Biology, November 2016, American Thoracic Society,
DOI: 10.1165/rcmb.2015-0349oc.
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