What is it about?

This is the first study to identify regional alterations in proteome patterns within the preterm lung and to describe how those patterns evolve over time within continuing ventilation.

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Why is it important?

A number of novel observations were made most notably that (1) the number of differentially expressed proteins was four-fold higher in the non-dependent lung than in the gravity-dependent lung and (2) that alterations in the proteome were observed as early as 15 minutes post ventilation commencing, with the complex changes increasing in number with continuing ventilation.


This is the second in our planned series of papers exploring alterations in the proteome. In our first we looked at the impact of gestational age on the proteome response to ventilation, and this paper uses the same methodology to provide regional snapshots of the lung. It's been an exciting journey creating new roadmaps to understanding the biology of preterm lung injury.

Prue Pereira-Fantini
Murdoch Children's Research Institute

Read the Original

This page is a summary of: Preterm Lung Exhibits Distinct Spatiotemporal Proteome Expression at Initiation of Lung Injury, American Journal of Respiratory Cell and Molecular Biology, November 2019, American Thoracic Society,
DOI: 10.1165/rcmb.2019-0084oc.
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