What is it about?
This study describes a convenient in vitro model of early granuloma formation that uses human peripheral blood immune cells that is demonstrated to share histological and molecular features of pulmonary sarcoidosis, and is further able to distinguish sarcoidosis from latent Mycobacterial tuberculosis based upon molecular signatures.
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Why is it important?
The lack of highly relevant models of early granuloma formation that accounts for complex human genetic traits represents a significant barrier to progress in the fields of sarcoidosis and tuberculosis.
Perspectives
We were thrilled to see that the in vitro granuloma model features were very similar to corresponding features of diseased human tissues. We are currently using the model to investigate mechanisms of early granuloma formation, and these early mechanisms are not evident from human tissues or from animal models. This model will also be useful for pre-clinical testing of novel therapeutic agents.
Elliott Crouser
The Ohio State University
Read the Original
This page is a summary of: A Novel In Vitro Human Granuloma Model of Sarcoidosis and Latent Tuberculosis Infection, American Journal of Respiratory Cell and Molecular Biology, October 2017, American Thoracic Society,
DOI: 10.1165/rcmb.2016-0321oc.
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