First-Onset Herpesviral Infection and Lung Injury in Allogeneic Hematopoietic Cell Transplantation

What is it about?

Virtually every human being carries latent herpesviruses, but the virus may reactivate during a period of immune suppression, such as after blood and bone marrow transplantation. We show that reactivation of herpesviruses in blood and marrow transplant recipients will increase their chances of developing lung injuries. In addition, we have established a mouse model of murine herpesvirus reactivation after bone marrow transplant, and shown that reactivated herpesvirus can cause lung injury after bone marrow transplant. This new animal model will be useful for testing treatment strategies.

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