The Y Chromosome Regulates BMPR2 Expression via SRY: A Possible Reason “Why” Fewer Males Develop Pulmonary Arterial Hypertension

What is it about?

Females develop PAH, a disease associated with reduced BMPR2 gene expression, more often than males. Female cells lack the male sex chromosome known as the Y chromosome. We show for the first time that a genetic factor on the Y chromosome (SRY) positively regulates BMPR2 expression. While further studies are needed, these findings suggest that male cells have an additional way to regulate BMPR2 expression (SRY), which may be another contributor to the difference in PAH incidence between females and males.

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