Nosocomial Pneumonia Elicits an Endothelial Proteinopathy: Evidence for a Source of Neurotoxic Amyloids in Critically Ill Patients

What is it about?

Intensive care patients are prone to neurological dysfunction, ranging from delirium to depression, anxiety, post-traumatic stress disorder, and dementia along the Alzheimer's Disease spectrum. This study demonstrates that bacteria-induced nosocomial pneumonia elicits lung endothelial cell production of cytotoxic amyloids that can impair neurological communication, and may contribute to problems in memory in critically ill patients.

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