What is it about?
We followed 514 kids and infants from 8 large children's hospitals to see if any recorded variables (lab tests, equipment, diagnoses, etc) were associated with an increased risk of needing a blood transfusion or clotting in the ecmo circuit or the patient.
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Why is it important?
This is the largest prospective evaluation of detailed information on consecutive pediatric ecmo patients in the literature that examines risk factors for bleeding or clotting. It gives us vital information on ways to develop best practice in the future
Perspectives
One issue identified in this study was that variability in practice between sites was associated with outcomes. This provides more evidence that standardizing how we do things to study a specific topic such as what is the best anticoagulation regimen, transfusion trigger or other questions may be needed--at least among study centers. It also provides more disappointing evidence that no current test or anticoagulation regimen seems better than another
Heidi Dalton
Inova Health System
Read the Original
This page is a summary of: Factors Associated with Bleeding and Thrombosis in Children Receiving Extracorporeal Membrane Oxygenation, American Review of Respiratory Disease, September 2017, American Thoracic Society,
DOI: 10.1164/rccm.201609-1945oc.
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