What is it about?

We have built a new model of the earliest stages of lung cancer by recreating key genetic changes in lung epithelial cells. We then use the model to understand what the biological impact of these changes are, and how we can interfere with them - the overall aim is to work towards the prevention of lung cancer in individuals at high risk.

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Why is it important?

Prevention is better than cure! If we can understand why cancer develops then we can potentially prevent it. This model really helps us work out what genes drive early lung cancer and what their impact is. We then took it further, and showed that we can use the model to test novel ways of using drugs to prevent lung cancer!

Perspectives

It's always fun to do something new in the lab and you're never sure exactly where experiments are going to take you. We have built a great new laboratory model that we are confident will have an impact in the clinic.

Frank McCaughan
University of Cambridge

Read the Original

This page is a summary of: SOX2 Drives Bronchial Dysplasia in a Novel Organotypic Model of Early Human Squamous Lung Cancer, American Review of Respiratory Disease, June 2017, American Thoracic Society,
DOI: 10.1164/rccm.201510-2084oc.
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Contributors

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