Is Progression of Pulmonary Fibrosis due to Ventilation-induced Lung Injury?

What is it about?

Pulmonary fibrosis progresses over years, presumably as a result of a self-sustaining injury but the cause of this ongoing injury is unknown. Ventilation-induced lung injury occurs as a result of atelectrauma and/or volutrauma in the setting of alveolar collapse. The pathology of pulmonary fibrosis includes alveolar collapse and surfactant abnormalities occur in patients with pulmonary fibrosis, with many of the risk factors and genetic variants associated with the condition, as well as in most of the models used to study it thereby potentially explaining why the collapse occurs. We suggest that the ongoing injury seen in pulmonary fibrosis is the result of ventilation-induced lung injury.

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