Abrupt Deflation after Sustained Inflation Causes Lung Injury

Bhushan H Katira, Doreen Engelberts, Gail Otulakowski, Regan E Giesinger, Takeshi Yoshida, Martin Post, Wolfgang M Kuebler, Kim A Connelly, Brian P Kavanagh
  • American Journal of Respiratory and Critical Care Medicine, June 2018, American Thoracic Society
  • DOI: 10.1164/rccm.201801-0178oc

What is it about?

Current Knowledge: Management of mechanical ventilation in ARDS focuses on ‘setting’ the ventilator parameter, including tidal volume and airway pressure; whether lung injury can occur secondary to abrupt deflation is not known. What this Study adds: Abrupt deflation after sustained inflation can injure previously healthy lungs. The mechanism appears to a surge of systemic cardiac output against vasoconstricted arteries which causes acute left ventricular decompensation, pulmonary edema and lung injury. If confirmed in patients with ARDS, this could have important implications.

The following have contributed to this page: Dr BRIAN P KAVANAGH