Drug-Penetration Gradients Associated with Acquired Drug Resistance in Patients with Tuberculosis

Keertan Dheda, Laura Lenders, Gesham Magombedze, Shashikant Srivastava, Prithvi Raj, Erland Arning, Paula Ashcraft, Teodoro Bottiglieri, Helen Wainwright, Timothy Pennel, Anthony Linegar, Loven Moodley, Anil Pooran, Jotam G. Pasipanodya, Frederick A. Sirgel, Paul D. van Helden, Edward Wakeland, Robin M. Warren, Tawanda Gumbo
  • American Journal of Respiratory and Critical Care Medicine, November 2018, American Thoracic Society
  • DOI: 10.1164/rccm.201711-2333oc

What is it about?

We examined the penetration of 8 drugs into tuberculosis lung cavities during long-term duration of tuberculosis, and the susceptibility of tubercle bacilli to these drugs. We found that that there were two gradient patterns to the drug penetration into cavities, and the steepness of these gradients and the low concentrations achieved inside cavities, drove the emergence of resistance. This led to a situation where some bacilli in the same cavity were drug-resistant while others were still susceptible.

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The following have contributed to this page: Dr Tawanda Gumbo