Mutations of Cystic Fibrosis Transmembrane Conductance Regulator Gene Cause a Monocyte-Selective Adhesion Deficiency

Claudio Sorio, Alessio Montresor, Matteo Bolomini-Vittori, Sara Caldrer, Barbara Rossi, Silvia Dusi, Stefano Angiari, Jan E. Johansson, Marzia Vezzalini, Teresinha Leal, Elisa Calcaterra, Baroukh M. Assael, Paola Melotti, Carlo Laudanna
  • American Journal of Respiratory and Critical Care Medicine, May 2016, American Thoracic Society
  • DOI: 10.1164/rccm.201510-1922oc

Leukocytes from patients affected by cystic fibrosis adhere and migrate differently than normal

What is it about?

Cell adhesion control inflammatory process in the body and its alteration are of pivotal importance being capable to affect the delicate balance necessary to control the extent and the efficacy of inflammatory response

Why is it important?

This result indicate for the first time that leukocytes from cystic fibrosis patients have a defect in cell adhesion and migration

The following have contributed to this page: Dr Claudio Sorio