Lactobacillus acidophilus LA85 reverses experimental diabetic sensory neuropathy by restoring redox homeostasis in the spinal cord

What is it about?

This is the first experimental study to demonstrate consistent therapeutic effects of Lactobacillus acidophilus treatment in painful diabetic neuropathy (DN) in murine models. Daily administration of L. acidophilus induced a sustained therapeutic effect that reveals its potential to induce long-lasting analgesia, associated with the reduction of glycemia and inflammatory mediators, in addition to the control of oxidative stress, favoring the reestablishment of redox homeostasis in the microenvironment of the nervous system of diabetic mice. Importantly, the present study showed that treatment with L. acidophilus was more effective than gabapentin in the DN model, the current treatment for relieving neuropathic pain in humans. These findings demonstrate the potential of the strain as a novel strategy for the treatment of sensory DN, which has been little reported in probiotic therapy.

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