What is it about?
no safe drugs exists that lower elevated plasma lipoprotein(a) concentrations and lipoprotein(a) is a highly atherogenic lipoprotein, FGF19 expression is induced by bile acids activated FXR which in turn represses apoA promoter via ELK1
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Why is it important?
These findings provide mechanistic insights into the transcriptional regulation of human APOA by FGF19 and could help to design FGF19 derivative able to reduce apoA and cardio vascular risks
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This page is a summary of: FGF19 Signaling Cascade Suppresses APOA Gene Expression, Arteriosclerosis Thrombosis and Vascular Biology, May 2012, Wolters Kluwer Health,
DOI: 10.1161/atvbaha.111.243055.
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