Anxiety in prognosis between HFrEF and HFpEF

What is it about?

Most studies have failed to support the prognostic relevance of anxiety in HFrEF or unclassified HF with mean LVEF < 40%. Meanwhile, the association between anxiety and prognoses in HFpEF remains unexamined. In our study, trait anxiety was independently associated with 18‐month all‐cause mortality, all‐cause readmission or death, and cardiac readmission or death in HFpEF, but not in HFrEF.

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Why is it important?

1. This study differentiated HFpEF from HFrEF phenotypes to compare the prognostic value of anxiety on 18‐month outcomes, including all‐cause mortality, cardiac mortality, all‐cause readmission or death, and cardiac readmission or death. 2. This is the first study to examine the prognostic relevance of anxiety symptoms in a consecutive cohort of patients with HFpEF; trait anxiety in patients with HFpEF, but not in those with HFrEF, during their hospital stay independently predicted 18‐month prognostic outcomes, including all‐cause mortality, all‐cause readmission or death, and cardiac readmission or death.