What is it about?
We identified a region of STING that is capable of activating downstream NFkB and revealed an autoinhibitory mechanism regulating STING activity. In quiescent state, STING LBD binds to its CTT and inhibits STING activity, whiel upon infection, STING binds to small molecule cGAMP and form oligomer, thus releases its CTT to activate downstream signaling.
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Why is it important?
It helps us to understand how STING is regulated, how it executes its antiviral function.
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This page is a summary of: Human STING Is Regulated by an Autoinhibitory Mechanism for Type I Interferon Production, Journal of Innate Immunity, February 2022, Karger Publishers,
DOI: 10.1159/000521734.
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